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Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. In patients who smoke, drug exposure decreases by approximately 20%. Singh, U. and Jialal, I. Alpha-lipoic acid supplementation and diabetes. Nutr Rev. Leaks Out Of Your.

How should I store PLETAL?

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Some products need acid so that the body can absorb them properly. decreases acid, so it may change how well these products work. Some research shows that receiving 600 mg of alpha-lipoic acid intravenously once daily for 2 weeks decreases blood sugar after eating. Klip, A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.

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Ask your doctor for a list of these medicines if you are not sure. You can ask your pharmacist for a list of medicines that interact with PLETAL. Know the medicines you take. Keep a list of them to show to your doctor and pharmacist when you get a new medicine. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Fu Y. Effects of alpha lipoic acid and mecobalamin on diabetic peripheral neuropathy. Chinese Journal of Practical Internal Medicine.

Use of cilostazol

VIATRIS GmbH. NATHAN II Study, data on file. When narrows the long arteries of the legs, your leg muscles don't get enough flow. Take S, Matsutani M, Ueda H et al. Effect of cilostazol in preventing restenosis after percutaneous transluminal coronary angioplasty. Am J Cardiol. Gastrointestinal side effects have included diarrhea 19% nausea 7% dyspepsia 6% abdominal pain 5% flatulence 3% and vomiting 2%. Other gastrointestinal side effects have included anorexia, cholelithiasis, colitis, duodenal ulcer, duodenitis, esophageal hemorrhage, esophagitis, increased GGT, gastritis, gastroenteritis, gum hemorrhage, hematemesis, melena, peptic ulcer, periodontal abscess, rectal hemorrhage, stomach ulcer, and tongue edema.



Does cilostazol interact with other medications

Park J. S. Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study. Excreted principally in urine 74% and also in feces 20% as active and inactive metabolites. Femiano, F. Burning mouth syndrome BMS: an open trial of comparative efficacy of alpha-lipoic acid thioctic acid with other therapies. Minerva Stomatol. No substantial differences in safety and efficacy relative to younger adults, but increased sensitivity cannot be ruled out. Cilostazol is usually taken twice a day on an empty stomach, at least 30 minutes before or 2 hours after breakfast or dinner. In the AT-BAT study, one patient died during a bradycardic episode 46 hours after a successful PCI, another patient required surgical revascularization, and one patient experienced no reflow requiring a temporary intra-aortic balloon.



General information about cilostazol

Jude, E. Diabetes Care, 2001; vol 24: pp 1433-1437. Cakatay, U. Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid. Let your doctor know right away if you have any bleeding episodes or signs of bleeding. Park SW, Lee CW, Kim HS et al. Comparison of cilostazol versus ticlopidine therapy after stent implantation. Am J Cardiol. Khan, B. V. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction ISLAND study. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding. Keep all regular medical and laboratory appointments. Store at room temperature away from moisture. not store in the bathroom. Keep all away from children and pets.



Who should not take PLETAL?

Bourdette, D. N. Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters. Mult. The following adverse reactions have been identified during post-approval use of PLETAL. Because these reactions are reported voluntarily from a population of an unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Do not use any medications containing esomeprazole while using omeprazole. Leon-Espinosa, S. Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study. Abolhassani, M. Adding a combination of hydroxycitrate and lipoic acid METABLOC to chemotherapy improves effectiveness against tumor development: experimental results and case report. Sabeel AI, Kurkus J, Lindholm T. Intensive Hemodialysis and Hemoperfusion Treatment of Amanita Mushroom Poisoning. Rooney, J. P. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Let your doctor know right away if you notice an irregular heartbeat or have dizziness or fainting episodes.



Cilostazol can make this condition worse

Richardson, R. S. Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Atarax hydroxyzine hydrochloride Canadian product monograph. Zhao, F. and Liu, Z. Q. Comparison of antioxidant effectiveness of lipoic acid and dihydrolipoic acid. J Biochem Mol. Cilostazol is extensively metabolized in the liver by the cytochrome P450 enzyme system, therefore, patients with significant hepatic dysfunction should receive 50 mg orally twice a day. Szygula, Z. Effect of cysteine derivatives administration in healthy men exposed to intense resistance exercise by evaluation of pro-antioxidant ratio. MI or stroke, no arrhythmias, no unstable angina or other signs of rapidly progressing cardiovascular disease. 1 2 13 19 Do not use in patients with CHF. 1 See Boxed Warning. Thompson, P. American Journal of Cardiology, 2002; vol 90: pp 1314-1319.



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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Take this medication by mouth without food as directed by your doctor, usually twice daily, at least 30 minutes before or 2 hours after breakfast and dinner. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Use this medication regularly to get the most benefit from it. Remember to use it at the same times each day. Zhou L. Effects of cilostazol and -lipoic acid on diabetic peripheral neuropathy. Journal of Medicine and Health Care. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Importance of informing patients of other important precautionary information. See Cautions. Suarez, P. and Clark, G. T. Burning mouth syndrome: an update on diagnosis and treatment methods. J Calif. What is the most important information I should know about cilostazol Pletal? PLETAL is available as 50 mg triangular and 100 mg round, white debossed tablets. Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Khan B. V. The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study. Taking hydroxyzine with agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening. Streeper RS, Henriksen EJ, Jacob S, et al. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Sun, H. alpha-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. November 2006 UTC Done.



Cilostazol adult dosage

Cilostazol MUST NOT be used during pregnancy. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Balestrieri, G. Insulin autoimmune syndrome induced by alpha-lipoic acid in a Caucasian woman: case report. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Dementia. Early evidence suggests that taking alpha-lipoic acid might slow down the decline of thinking skills in people with various kinds of dementia. However, almost a year of treatment may be needed. Gvozdjakova, A. Complementary therapy in diabetic patients with chronic complications: a pilot study. Bratisl. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Kim, G. S. alpha-Lipoic Acid Inhibits TNF-alpha-Induced Apoptosis in Human Bone Marrow Stromal Cells. J Bone Miner. What are the possible side effects of cilostazol Pletal? Take this medication by as directed by your doctor, usually once daily, before a meal. If you are self-treating, follow all directions on the product package. Dosage and length of treatment are based on your medical condition and response to treatment. Do not stop taking any medications without consulting your healthcare provider.



Reviews for cilostazol

Aisen P. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. The recommended dosage of PLETAL is 100 mg twice daily taken at least half an hour before or two hours after breakfast and dinner. Ametov AS, Barinov A, Dyck PJ, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid. Cho, H. S. A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. Pharmacokinetics are approximately dose proportional. Cilostazol and its active metabolites have apparent elimination half-lives of about 11-13 hours. Cilostazol and its active metabolites accumulate about 2-fold with chronic administration and reach steady state blood levels within a few days. The pharmacokinetics of cilostazol and its two major active metabolites were similar in healthy subjects and patients with due to peripheral arterial disease . Figure 1 shows the mean plasma concentration-time profile at steady state after multiple dosing of PLETAL 100 mg twice daily. Less frequent clinical significant adverse reactions less than 2% that were experienced by patients treated with PLETAL 50 mg twice daily or 100 mg twice daily in the eight controlled clinical trials and that occurred at a frequency in the 100 mg twice daily group greater than in the placebo group are listed below. Distributed into milk in rats; 1 discontinue nursing or drug because of potential risk in nursing infants. Treadwell, B. V. Loss of taste responds to high-dose biotin treatment. J Am Coll. Neuzil J. alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy. Matalon R, Stumpf DA, Michals K, et al. Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid. Mazloom, Z. and Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. McGee, S. Archives of Internal Medicine, 1998; vol 158: pp 1357-1364. PLETAL has been shown to be in rats at doses that are greater than 5-times the human MRHD on a body surface area basis. There are no adequate and well-controlled studies in pregnant women.



Cilostazol brand names

Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Bartlett, H. E. and Eperjesi, F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt. Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Assessing the Potential Risk of Abnormal Heart Rhythm. It works by decreasing the amount of acid your makes. Not studied in patients with moderate to severe hepatic impairment; 1 2 19 use with caution. Kunishima T, Musha H, Eto F et al. A randomized trial of aspirin versus cilostazol therapy after successful coronary stent implantation. Clin Ther. Gilron, I. Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database. Has been used for secondary prevention of noncardioembolic stroke or TIAs in patients with a history of TIAs or ischemic stroke. Figure 2 depicts the percent mean improvement in maximal walking distance, at study end for each of the eight studies. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Pletal; it may harm a fetus. Pletal passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding. Konrad, T. Pharmacodynamic effects of orally administered dexlipotam on endothelial function in type 2-diabetic patients. Int. If your doctor has prescribed this for you, not share it with others. Discuss the risks and benefits with your doctor. Cilostazol is an antiplatelet drug and a vasodilator. It works by stopping called platelets from sticking together and prevents them from forming harmful clots. It also widens blood vessels in the legs. Cilostazol helps the blood to move more easily and keeps blood flowing smoothly in your body.



What are the possible side effects of cilostazol

Its long-term effects on limb preservation and hospitalization have not been evaluated. This information is generalized and not intended as specific medical advice. Ulbig M. W. Alpha-lipoic acid for the prevention of diabetic macular edema. Packer, L. Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem. Lewis, G. F. Short-term oral alpha-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men. Am J Physiol Endocrinol. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Leng, G. Cochrane Database of Systematic Reviews, 2000; CD000990. Metabolized to active metabolites in the liver by CYP isoenzymes, principally CYP3A4, and to lesser extent, by CYP2C19. How should I store PLETAL? Park, J. Y. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem.



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Indications and usage of cilostazol


MRHD on a systemic exposure basis

These may increase the risk of serious side effects. Szyszka, K. Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise. For severe peripheral artery disease, your doctor may recommend surgery or less invasive procedures to bypass a blocked artery and restore blood flow. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Cilostazol dosage

Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid alpha-lipoic acid in symptomatic diabetic polyneuropathy. Do not share this medication with others. This has been prescribed for your current condition only. not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in that case. Wolzt, M. Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus. Transl. Wei GY. Effects of mecobalamin and -lipoic acid on diabetic peripheral neuropathy. Journal of Traditional Chinese Medicine.

Cilostazol uses

Block G, Jensen C, Dietrich M, et al. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. Wen SL. Effects of alpha-lipoic acid on painful neuropathy of type 2 diabetes. Journal of Henan University. Talk with your doctor about an exercise program to improve walking and decrease pain.

How should I take PLETAL?

Do not use on large areas of the body, apply heat or cover the area with waterproof bandages or plastic unless directed to do so by your doctor. Otsuka America Pharmaceutical, Inc. Pletal cilostazol tablets prescribing information. Rockville, MD; 2007 May. Altenkirch H, Stoltenburg-Didinger G, Wagner HM, et al. Effects of lipoic acid in hexacarbon-induced neuropathy.

Nonalcholic liver inflammation steatohepatitis. Early evidence suggests that taking 600-900 mg of alpha-lipoic acid dialy for 2 months might reduce liver size and symptoms in people with nonalcoholic liver inflammation. Atarashi H, Endoh Y, Saitoh H, Kishida H, Hayakawa H "Chronotropic effects of cilostazol, a new antithrombotic agent, in patients with bradyarrhythmias. This may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Flora, S. J. Arsenic-induced oxidative stress and its reversibility. Free Radic.

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